.MXD file extension

This is the basic program to work with .MXD extension

ArcGIS License Manager

ArcGIS License Manager ESRI ArcMap Document

The program works with the following extensions: gnd, mxd, mxt, sxd, sxt, 3dd and 3dt

.MXD extension is also supported by the following programs:

Mids' Hero Designer

Mids' Hero Designer Hero/Villain Build

Mids' Hero Designer enables you to plan your hero or villain's build.
PLTS for ArcGIS - Foundation

PLTS for ArcGIS - Foundation ESRI ArcMap Document

PLTS for ArcGIS -Foundation is a collection of turnkey software applications.
ArcView GIS Version

ArcView GIS Version ESRI ArcMap Document

ArcGIS for Desktop

ArcGIS for Desktop ESRI ArcMap Document

Easily create and share information with individuals, groups, or organizations.